Pro BDNF (proBDNF)
(Pro-Brain-Derived Neurotrophic Factor (proBDNF))
Protein-Typ
Recombinant
Spezies
Human
Quelle
Escherichia coli (E. coli)
Verwendungszweck
Recombinant Human Pro-Brain-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala19-Arg247(R125A, R127A, R128A) is expressed.
Produktmerkmale
Extracellular Domain Protein
Aufreinigung
Affinity purification
Reinheit
Greater than 95 % as determined by reducing SDS-PAGE.
proBDNF
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
>98 %
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution of PBS, pH 8.0.
Lagerung
-20 °C,-80 °C
Informationen zur Lagerung
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Haltbarkeit
12 months
Target
Pro BDNF (proBDNF)
(Pro-Brain-Derived Neurotrophic Factor (proBDNF))
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.