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Pro BDNF Protein

proBDNF Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7455668
  • Target Alle Pro BDNF (proBDNF) Produkte
    Pro BDNF (proBDNF) (Pro-Brain-Derived Neurotrophic Factor (proBDNF))
    Protein-Typ
    Recombinant
    Spezies
    • 2
    • 1
    Human
    Quelle
    • 3
    Escherichia coli (E. coli)
    Verwendungszweck
    Recombinant Human Pro-Brain-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala19-Arg247(R125A, R127A, R128A) is expressed.
    Produktmerkmale
    Extracellular Domain Protein
    Aufreinigung
    Affinity purification
    Reinheit
    Greater than 95 % as determined by reducing SDS-PAGE.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 8.0.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Haltbarkeit
    12 months
  • Target
    Pro BDNF (proBDNF) (Pro-Brain-Derived Neurotrophic Factor (proBDNF))
    Andere Bezeichnung
    pro-BDNF (proBDNF Produkte)
    Hintergrund
    The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
    Molekulargewicht
    25.6 KDa
    UniProt
    P23560
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