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TSH receptor Protein

TSHR Spezies: Human Wirt: HEK-293 Cells Synthetic Nanodisc
Produktnummer ABIN7491755
  • Target Alle TSH receptor (TSHR) Proteine anzeigen
    TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
    Protein-Typ
    Synthetic Nanodisc
    Spezies
    • 4
    • 1
    Human
    Quelle
    • 3
    • 1
    • 1
    HEK-293 Cells
    Verwendungszweck
    Human TSHR full length protein-synthetic nanodisc
    Produktmerkmale
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
  • Kommentare

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Haltbarkeit
    12 months
  • Target
    TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
    Andere Bezeichnung
    TSHR (TSHR Produkte)
    Synonyme
    CHNG1 Protein, LGR3 Protein, hTSHR-I Protein, AI481368 Protein, hypothroid Protein, hyt Protein, pet Protein, TSHRA Protein, TSH-R Protein, thyroid stimulating hormone receptor Protein, tshr Protein, TSHR Protein, Tshr Protein
    Hintergrund
    The protein is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism.
    Molekulargewicht
    The human full length TSHR protein has a MW of 86.8 kDa
    UniProt
    P16473
    Pathways
    Thyroid Hormone Synthesis
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