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LGR5 Protein

LGR5 Spezies: Human Wirt: HEK-293 Cells Synthetic Nanodisc
Produktnummer ABIN7491689
  • Target Alle LGR5 Proteine anzeigen
    LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
    Protein-Typ
    Synthetic Nanodisc
    Spezies
    • 4
    • 1
    • 1
    Human
    Quelle
    • 3
    • 2
    • 1
    HEK-293 Cells
    Verwendungszweck
    Human LGR5 full length protein-synthetic nanodisc
    Produktmerkmale
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
    Top Product
    Discover our top product LGR5 Protein
  • Kommentare

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Haltbarkeit
    12 months
  • Target
    LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
    Andere Bezeichnung
    LGR5 (LGR5 Produkte)
    Synonyme
    lgr5-a Protein, lgr5a Protein, FEX Protein, Gpr49 Protein, GPR49 Protein, GPR67 Protein, GRP49 Protein, HG38 Protein, leucine-rich repeat containing G protein-coupled receptor 5 L homeolog Protein, leucine rich repeat containing G protein coupled receptor 5 Protein, leucine rich repeat containing G protein-coupled receptor 5 Protein, lgr5.L Protein, Lgr5 Protein, LGR5 Protein
    Hintergrund
    The protein is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene.
    Molekulargewicht
    The human full length LGR5 protein has a MW of 100.0 kDa
    UniProt
    O75473
    Pathways
    WNT Signalweg
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