PTGER4 Protein
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- Target Alle PTGER4 Proteine anzeigen
- PTGER4 (Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4))
- Protein-Typ
- Synthetic Nanodisc
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Verwendungszweck
- Human PTGER4 full length protein-synthetic nanodisc
- Produktmerkmale
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
- Top Product
- Discover our top product PTGER4 Protein
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- Kommentare
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Haltbarkeit
- 12 months
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- Target
- PTGER4 (Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4))
- Andere Bezeichnung
- PTGER4 (PTGER4 Produkte)
- Synonyme
- EP4 Protein, PGE2R-EP4 Protein, ptger4 Protein, ptger4l Protein, PTGER4 Protein, EP4R Protein, Ptgerep4 Protein, Ptger Protein, ep4 Protein, prostaglandin E receptor 4 Protein, prostaglandin E receptor 4 (subtype EP4) Protein, prostaglandin E receptor 4 (subtype EP4) a Protein, prostaglandin E receptor 4 subtype EP4 Protein, PTGER4 Protein, ptger4a Protein, ptger4 Protein, Ptger4 Protein
- Hintergrund
- The protein is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.
- Molekulargewicht
- The human full length PTGER4 protein has a MW of 53.1 kDa
- UniProt
- P35408
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