TRPV1 Protein
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- Target Alle TRPV1 Proteine anzeigen
- TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))
- Protein-Typ
- Synthetic Nanodisc
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Verwendungszweck
- Human TRPV1 full length protein-synthetic nanodisc
- Produktmerkmale
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
- Top Product
- Discover our top product TRPV1 Protein
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- Kommentare
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Haltbarkeit
- 12 months
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- Target
- TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))
- Andere Bezeichnung
- TRPV1 (TRPV1 Produkte)
- Synonyme
- si:dkey-9e15.2 Protein, VR.5'sv Protein, Vr1 Protein, Vr1l1 Protein, VR1 Protein, OTRPC1 Protein, TRPV1alpha Protein, TRPV1beta Protein, VR-1 Protein, transient receptor potential cation channel, subfamily V, member 1 Protein, transient receptor potential cation channel subfamily V member 1 Protein, trpv1 Protein, Trpv1 Protein, TRPV1 Protein
- Hintergrund
- Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
- Molekulargewicht
- The human full length TRPV1 protein has a MW of 95.0 kDa
- UniProt
- Q8NER1
- Pathways
- Dicarboxylic Acid Transport
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