APCDD1 Protein (AA 27-492)

Produktnummer ABIN7504233

Produktdetails

Target: APCDD1 (Adenomatosis Polyposis Coli Down-Regulated 1 (APCDD1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 27-492

Spezies: Human

Quelle: HEK-293 Cells

Verwendungszweck: Human APCDD1 Protein

Sequenz: Leu27-His492

Produktmerkmale: Recombinant Human APCDD1 Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Leu27-His492.

Reinheit: > 95 % as determined by Tris-Bis PAGE

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: APCDD1 (Adenomatosis Polyposis Coli Down-Regulated 1 (APCDD1))

Andere Bezeichnung: APCDD1 (APCDD1 Produkte)

Synonyme: drapc1 Protein, xPgo Protein, APCDD1 Protein, Pgo1 Protein, cAPCDD1 Protein, B7323 Protein, DRAPC1 Protein, HHS Protein, HTS Protein, AB023957 Protein, AU041258 Protein, Drapc1 Protein, EIG180 Protein, adenomatosis polyposis coli down-regulated 1 Protein, APC down-regulated 1 Protein, adenomatosis polyposis coli down-regulated 1 L homeolog Protein, apcdd1 Protein, APCDD1 Protein, Apcdd1 Protein, apcdd1.L Protein

Hintergrund: Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mechanisms underlying Wnt signaling tooth development. In situ hybridization showed that Apcdd1 was expressed in the condensed mesenchyme at the bud stage, and in the inner enamel epithelium (IEE), including enamel knot (EK) at the cap stage. APCDD1 modulates the gene expression of Wnt- and EK-related signaling molecules at the cap stage of tooth development, and is involved in tooth cusp patterning by modulating the epithelial rearrangement in the IEE.

Molekulargewicht: 80.06 kDa. Due to glycosylation, the protein migrates to 82-110 kDa based on Tris-Bis PAGE result.

UniProt: Q8J025