ABL1 Protein (AA 1-264) (His tag)

Produktnummer ABIN7504918

Produktdetails

Target: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-264

Spezies: Cynomolgus

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses ABL1 Protein ist gelabelt mit His tag.

Sequenz: Met 1-Phe 264

Produktmerkmale: A DNA sequence encoding theCynomolgus macaques ABL1 protein (A0A2K5X6F2) (Met 1-Phe 264) was expressed with N-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Andere Bezeichnung: ABL1 (ABL1 Produkte)

Synonyme: ABL Protein, JTK7 Protein, bcr/abl Protein, c-ABL Protein, p150 Protein, v-abl Protein, AI325092 Protein, Abl Protein, E430008G22Rik Protein, c-Abl Protein, ABL proto-oncogene 1, non-receptor tyrosine kinase Protein, c-abl oncogene 1, non-receptor tyrosine kinase Protein, Tyrosine-protein kinase abl-1 Protein, ABL1 Protein, Abl1 Protein, abl-1 Protein, abl1 Protein

Hintergrund:

Abbreviation: ABL1

Target Synonym: Abelson tyrosine protein kinase 1,ABL 1,bcr/abl,JTK7,p150,Proto-oncogene c-Abl,v abl

Background: Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Molekulargewicht:

Calculated MW: 28.93 kDa

Observed MW: 35 kDa

UniProt: A0A2K5X6F2

Pathways: Apoptose, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism