Lipocalin 2 Protein (LCN2) (AA 21-198) (His tag)
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- Target Alle Lipocalin 2 (LCN2) Proteine anzeigen
- Lipocalin 2 (LCN2)
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 21-198
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses Lipocalin 2 Protein ist gelabelt mit His tag.
- Sequenz
- Gln21-Gly198
- Produktmerkmale
- A DNA sequence encoding the Human NGAL/LCN2 (P80188-1) (Gln21-Gly198) was expressed with a polyhistidine tag at the N-terminus.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product LCN2 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Haltbarkeit
- 12 months
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- Target
- Lipocalin 2 (LCN2)
- Andere Bezeichnung
- NGAL (LCN2 Produkte)
- Synonyme
- LCN2 Protein, 24p3 Protein, MSFI Protein, NGAL Protein, AW212229 Protein, Sip24 Protein, lipocalin 2 Protein, LCN2 Protein, Lcn2 Protein
- Hintergrund
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Abbreviation: NGAL,LCN2
Target Synonym: 24p3,25 kDa Alpha 2 Microglobulin Related Subunit of MMP9,Alpha 2 Microglobulin Related Protein,HGNC:6526,Lcn 2,Lipocalin-2,Migration Stimulating Factor Inhibitor,MSFI,Oncogene 24p3,p25,Siderocalin,Siderocalin LCN2,SV40 induced 24P3 Protein,Uterocalin,Neutrophil Gelatinase Associated Lipocalin
Background: Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.
- Molekulargewicht
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Calculated MW: 20.5 kDa
Observed MW: 19 kDa
- UniProt
- P80188-1
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis
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