NFATC4 Protein (AA 401-683) (His tag)
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- Target Alle NFATC4 Proteine anzeigen
- NFATC4 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4 (NFATC4))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 401-683
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses NFATC4 Protein ist gelabelt mit His tag.
- Applikation
- Immunogen (Imm)
- Sequenz
- Ser401-Phe683
- Produktmerkmale
- A DNA sequence encoding the Human NFATC4 (Q14934-1) (401S-683F) was expressed with a polyhistidine tag at the N-terminus.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product NFATC4 Protein
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4., 5 % trehalose, 5 % mannitol, 0.01 % tween-80.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Haltbarkeit
- 12 months
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- Target
- NFATC4 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4 (NFATC4))
- Andere Bezeichnung
- NFATC4 (NFATC4 Produkte)
- Synonyme
- si:dkeyp-66d1.4 Protein, NFATC4 Protein, 3110041H08Rik Protein, AW107667 Protein, AW546455 Protein, Nfat3 Protein, NF-ATc4 Protein, NFAT3 Protein, nuclear factor of activated T-cells 4 Protein, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 Protein, nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 Protein, NFATC4 Protein, nfatc4 Protein, Nfatc4 Protein
- Hintergrund
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Abbreviation: NFATC4
Target Synonym: cytoplasmic 4,NF ATc4,NF-AT3,NF-ATc4,NFAC4_HUMAN,NFAT3,NFATc4,Nuclear factor of activated T cells cytoplasmic 4,Nuclear factor of activated T cells cytoplasmic calcineurin dependent 4,Nuclear factor of activated T-cells,T cell transcription factor NFAT3,T-cell transcription factor NFAT3
Background: Ca2+-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4. Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function. Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC. Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival. Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) . Plays a role in adipocyte differentiation. May be involved in myoblast differentiation into myotubes. Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription. Binds to PPARG gene promoter and regulates its activity. Binds to PPARG and REG3G gene promoters.
- Molekulargewicht
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Calculated MW: 31.5 kDa
Observed MW: 31-33 kDa
- UniProt
- Q14934-1
- Pathways
- RTK Signalweg, WNT Signalweg
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