CD74 Protein (AA 73-296) (His tag)

Produktnummer ABIN7504958

Produktdetails

Target: CD74 (HLA-DR-gamma (CD74))

Protein-Typ: Recombinant

Proteineigenschaft: AA 73-296

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CD74 Protein ist gelabelt mit His tag.

Applikation: Immunogen (Imm)

Sequenz: Gln73-Met296

Produktmerkmale: A DNA sequence encoding theHuman CD74 protein (P04233) (73Q-296M) was expressed with a polyhistidine tag at the N-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

used as Immunogen for (ABIN6999918, ABIN7234286, ABIN7234287 and ABIN7234288)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: CD74 (HLA-DR-gamma (CD74))

Andere Bezeichnung: CD74 (CD74 Produkte)

Synonyme: DHLAG Protein, HLADG Protein, II Protein, Ia-GAMMA Protein, CLIP Protein, Ii Protein, INVG34 Protein, Iclp-1 Protein, iclp1 Protein, wu:fb11f09 Protein, wu:fb12a01 Protein, wu:fb13d06 Protein, wu:fk94e07 Protein, Iclp-2 Protein, cd74 Protein, iclp2 Protein, zgc:123161 Protein, CD74 molecule Protein, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) Protein, CD74 molecule, major histocompatibility complex, class II invariant chain a Protein, CD74 molecule, major histocompatibility complex, class II invariant chain b Protein, CD74 Protein, Cd74 Protein, cd74a Protein, cd74b Protein

Hintergrund:

Abbreviation: CD74

Target Synonym: CD 74,CD74 antigen (invariant polypeptide of major histocompatibility complex,class II antigen-associated),CD74 Molecule,major histocompatibility complex,class II invariant chain,CLIP,DHLAG,Gamma chain of class II antigens,HG2A,HLA class II histocompatibility antigen gamma chain,HLA DR antigens associated invariant chain,HLA DR gamma,HLA-DR antigens-associated invariant chain,HLA-DR-gamma,HLADG,HLADR antigens associated invariant chain,Ia antigen associated invariant chain,Ia antigen-associated invariant chain,Ia associated invariant chain,Ia gamma,Invariant polypeptide of major histocompatibility complex class II antigen associated,la-gamma,Major histocompatibility complex class II invariant chain,MHC HLA DR gamma chain,MHC HLA-DR gamma chain,p33,p35,Protein 41

Background: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Molekulargewicht:

Calculated MW: 26.6 kDa

Observed MW: 30-33 kDa

UniProt: P04233

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints