E-cadherin Protein (AA 155-375) (His tag)

Produktnummer ABIN7504962

Produktdetails

Target: E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 155-375

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses E-cadherin Protein ist gelabelt mit His tag.

Applikation: Immunogen (Imm)

Sequenz: Asp155-Phe375

Produktmerkmale: A DNA sequence encoding the Human CDH1 (P12830-1) (Asp155-Phe375) was expressed with a polyhistidine tag at the N-terminus.

Reinheit: > 85 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

used as Immunogen for (ABIN6999858, ABIN7234109, ABIN7234110 and ABIN7234111)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))

Andere Bezeichnung: CDH1 (CDH1 Produkte)

Synonyme: Arc-1 Protein, CD324 Protein, CDHE Protein, ECAD Protein, LCAM Protein, UVO Protein, E-cadherin Protein, cdh1 Protein, si:dz180o5.2 Protein, uvo Protein, lcam Protein, E-Cad Protein, XBcad Protein, l-cam Protein, xcdh1 Protein, cdhc-A Protein, xb-cad Protein, XTCAD-1 Protein, c-cadherin Protein, cadherin-1 Protein, uvomorulin Protein, XB-cadherin Protein, arc-1 Protein, cd324 Protein, cdhe Protein, ecad Protein, AA960649 Protein, E-cad Protein, Ecad Protein, L-CAM Protein, Um Protein, cadherin 1 Protein, si:busm1-180o5.2 Protein, cadherin 1, type 1, E-cadherin (epithelial) Protein, cadherin 1, type 1 S homeolog Protein, CDH1 Protein, si:busm1-180o5.2 Protein, cdh1 Protein, Cdh1 Protein, cdh1.S Protein

Hintergrund:

Abbreviation: CDH1

Target Synonym: Arc 1,CADH1,Cadherin 1,cadherin 1 type 1 E-cadherin,Cadherin1,CAM 120/80,CD 324,CD324,CD324 antigen,cdh1,CDHE,E-Cad/CTF3,E-cadherin,ECAD,Epithelial cadherin,epithelial calcium dependant adhesion protein,LCAM,Liver cell adhesion molecule,UVO,Uvomorulin

Background: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.

Molekulargewicht:

Calculated MW: 23.9 kDa

Observed MW: 35 kDa

UniProt: P12830-1

Pathways: WNT Signalweg, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation