NADPH Oxidase 4 Protein (NOX4) (AA 220-392) (His tag)

Produktnummer ABIN7505064

Produktdetails

Target: NADPH Oxidase 4 (NOX4)

Protein-Typ: Recombinant

Proteineigenschaft: AA 220-392

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses NADPH Oxidase 4 Protein ist gelabelt mit His tag.

Sequenz: Asp 220-Asp 392

Produktmerkmale: A DNA sequence encoding the Human NOX4 protein (Q9NPH5) (Asp 220-Asp 392) was expressed with a N-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: NADPH Oxidase 4 (NOX4)

Andere Bezeichnung: NOX4 (NOX4 Produkte)

Synonyme: KOX Protein, KOX-1 Protein, RENOX Protein, AI648021 Protein, nox4 Protein, NOX4 Protein, NADPH oxidase 4 Protein, NOX4 Protein, Nox4 Protein, nox4 Protein, PTRG_09562 Protein

Hintergrund:

Abbreviation: NOX4

Target Synonym: KOX 1,KOX,Kox-1,KOX1,NADPH,NADPH oxidase Nox4,NOX4,Renal NAD(P)H oxidase,Renal NAD(P)H-oxidase,RENOX

Background: NADPH Oxidase 4/NOX4, also known as Renal NADPH Oxidase/RENOX and Kidney Oxidase 1/KOX1, is a 66 to 75 kDa member of the NOX family of NADPH oxidases. NOX family members are a major source of reactive oxygen species (ROS), including hydrogen peroxide and superoxide, and are critical mediators of redox signaling. NOX4 is strongly expressed in the kidney, especially in the proximal convoluted tubule cells of the renal cortex, and may function as an oxygen sensor that regulates the synthesis of erythropoietin. Expression is also high in endothelial cells, and because aortas from deficient mice exhibit increased inflammation, hypertrophy and endothelial dysfunction, NOX4 may function to protect the vasculature during ischemic or inflammatory stress. Human NOX4 is 578 amino acids (aa) in length, with several additional smaller isoforms identified. Over aa 450-578, human NOX4 has 92 % sequence identity with mouse NOX4, and 91 % identity with rat NOX4.

Molekulargewicht:

Calculated MW: 18.92 kDa

Observed MW: 18 kDa

UniProt: Q9NPH5

Pathways: Carbohydrate Homeostasis, Smooth Muscle Cell Migration