IDE Protein (AA 753-973) (His tag)

Produktnummer ABIN7505065

Produktdetails

Target: IDE (Insulin-Degrading Enzyme (IDE))

Protein-Typ: Recombinant

Proteineigenschaft: AA 753-973

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses IDE Protein ist gelabelt mit His tag.

Sequenz: Ala 753-Pro 973

Produktmerkmale: A DNA sequence encoding the Human IDE protein (P14735) (Ala 753-Pro 973) was expressed with a N-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: IDE (Insulin-Degrading Enzyme (IDE))

Andere Bezeichnung: IDE (IDE Produkte)

Synonyme: zgc:162603 Protein, IDE Protein, 1300012G03Rik Protein, 4833415K22Rik Protein, AA675336 Protein, AI507533 Protein, INSDEGM Protein, INSULYSIN Protein, insulin degrading enzyme Protein, insulin-degrading enzyme Protein, metallopeptidase Protein, IDE Protein, ide Protein, LOC591315 Protein, CC1G_01115 Protein, Bm1_26615 Protein, PTRG_10875 Protein, SJAG_01430 Protein, EBI_21700 Protein, VDBG_06702 Protein, LOAG_08082 Protein, PGTG_04982 Protein, Tsp_00424 Protein, Ide Protein

Hintergrund:

Abbreviation: IDE

Target Synonym: Insulin-Degrading Enzyme,Abeta-Degrading Protease,Insulin Protease,Insulinase,Insulysin,IDE

Background: Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted amyloid β-protein by neurons and microglia. IDE, which migrates at 110 kDa during gel electrophoresis under denaturing conditions, has since been shown to have additional substrates, including the signaling peptides glucagon, TGF α and β-endorphin.

Molekulargewicht:

Calculated MW: 24.2 kDa

Observed MW: 32 kDa

UniProt: P14735

Pathways: SARS-CoV-2 Protein Interaktom