ADA Protein (AA 11-280) (His tag)

Produktnummer ABIN7505066

Produktdetails

Target: ADA (Adenosine Deaminase (ADA))

Protein-Typ: Recombinant

Proteineigenschaft: AA 11-280

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses ADA Protein ist gelabelt mit His tag.

Sequenz: Lys 11-Val 280

Produktmerkmale: A DNA sequence encoding the Human ADA protein (P00813) (Lys 11-Val 280) was expressed with a N-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: ADA (Adenosine Deaminase (ADA))

Andere Bezeichnung: ADA (ADA Produkte)

Synonyme: ADA-like Protein, xada Protein, ADA Protein, CG11994 Protein, Dmel\\CG11994 Protein, DrosADA Protein, dADA Protein, zgc:92028 Protein, adenosine deaminase Protein, adenosine deaminase S homeolog Protein, Adenosine deaminase Protein, ADA Protein, Ada Protein, ada.S Protein, ada Protein

Hintergrund:

Abbreviation: ADA

Target Synonym: ADA,ADA1,adenine deaminase,Adenosine aminohydrolase,Adenosine Deaminase,EC 3.5.4.4

Background: Adenosine Deaminase (ADA, adenosine aminohydrolase) is one of the key enzymes of purine nucleotide catabolism. It catalyses the hydrolytic deamination of adenosine and deoxy?adenosine to inosine and deoxyinosine. ADA is expressed in virtually all tissues and is expressed at high levels in T-lymphocytes. Adenosine Deaminase deficiency can cause a form of SCID (severe combined immunodeficiency) and lymphopenia in both B- and T-cell lineages ADA can be used as a sensitive diagnostic marker for tuberculous pleuritis. Although it is primarily a cytosolic enzyme, ADA is known to be a positive regulator of T-cell co?activation due to its binding to CD26 at the cell surface. The interaction of ADA with CD26 regulates lymphocyte-epithelial cell adhesion.

Molekulargewicht:

Calculated MW: 29.59 kDa

Observed MW: 32 kDa

UniProt: P00813

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Ribonucleoside Biosynthetic Process