MMP7 Protein (AA 95-267) (His tag)

Produktnummer ABIN7505088

Produktdetails

Target: MMP7 (Matrix Metallopeptidase 7 (Matrilysin, Uterine) (MMP7))

Protein-Typ: Recombinant

Proteineigenschaft: AA 95-267

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses MMP7 Protein ist gelabelt mit His tag.

Sequenz: Tyr 95-Lys 267

Produktmerkmale: A DNA sequence encoding the Human MMP-7 protein (P09237) (Tyr 95-Lys 267) was expressed with a N-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: MMP7 (Matrix Metallopeptidase 7 (Matrilysin, Uterine) (MMP7))

Andere Bezeichnung: MMP-7 (MMP7 Produkte)

Synonyme: MAT Protein, MPMM Protein, MMP-7 Protein, MPSL1 Protein, PUMP-1 Protein, matrilysin Protein, LOC727698 Protein, MMP7 Protein, Matrilysin Protein, matrix metallopeptidase 7 Protein, MMP7 Protein, Mmp7 Protein

Hintergrund:

Abbreviation: MMP-7

Target Synonym: MMP-7,MPSL1,PUMP-1

Background: Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-7 (matrilysin) is expressed in epithelial cells of normal and diseased tissues, and is capable of digesting a large series of proteins of the extracellular matrix including collagen IV and X, gelatin, casein, laminin, aggrecan, entactin, elastin and versican. MMP-7 is implicated in the activation of other proteinases such as plasminogen, MMP-1, MMP-2, and MMP-9. In addition to its roles in connective tissue remodeling and cancer, MMP-7 also regulates intestinal alpha ?defensin activation in innate host defense, releases tumor necrosis factor-alpha in a model of herniated disc resorption, and cleaves FasL to generate a soluble form in a model of prostate involution. Structurally, MMP-7 is the smallest of the MMPs and consists of two domains: a pro-domain that is cleaved upon activation and a catalytic domain containing the zinc-binding site.

Molekulargewicht:

Calculated MW: 18.92 kDa

Observed MW: 20 kDa

UniProt: P09237

Pathways: Production of Molecular Mediator of Immune Response