FGF23 Protein (AA 24-126) (SUMO Tag,His tag)

Produktnummer ABIN7505101

Produktdetails

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Protein-Typ: Recombinant

Proteineigenschaft: AA 24-126

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses FGF23 Protein ist gelabelt mit SUMO Tag,His tag.

Sequenz: Ala 24-Val 126

Produktmerkmale: A DNA sequence encoding the Human FGF23 protein (Q9GZV9) (Ala 24-Val 126) was expressed with a N-SUMO-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Andere Bezeichnung: FGF23 (FGF23 Produkte)

Synonyme: FGF23 Protein, ADHR Protein, FGFN Protein, HPDR2 Protein, HYPF Protein, PHPTC Protein, fibroblast growth factor 23 Protein, fgf23 Protein, FGF23 Protein, Fgf23 Protein

Hintergrund:

Abbreviation: FGF23

Target Synonym: FGF-23,Fgf23,ADHR,FGF23,fibroblast growth factor 23,HPDR2,HYPF,phosphatonin,PHPTC

Background: Fibroblast growth factor 23 (FGF?23) is a 30?32 kDa member of the FGF family, within a subfamily that also includes FGF?19 and FGF?21. FGF proteins contain a 120 amino acid (aa) core FGF domain that exhibits a beta ?trefoil structure. FGF?19 subfamily members are highly diffusible molecules owing to their poor ECM/heparin sulfate binding and plasma?stabilizing intramolecular folds. FGF?23 is produced by osteocytes and osteoblasts in response to high circulating phosphate levels, elevated parathyroid hormone, and circulatory volume loading. It functions as an endocrine phosphatonin by suppressing circulating phosphate levels . FGF?23 interaction with renal proximal tubular epithelium decreases the renal resorption of phosphate by down?regulating phosphate transporters and by suppressing vitamin D production. It also decreases the intestinal absorption of phosphate.

Molekulargewicht:

Calculated MW: 31.22 kDa

Observed MW: 32 kDa

UniProt: Q9GZV9

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Negative Regulation of Hormone Secretion