LGALS1/Galectin 1 Protein (AA 1-135) (His tag)

Produktnummer ABIN7505140

Produktdetails

Target: LGALS1/Galectin 1 (LGALS1) (Lectin, Galactoside-Binding, Soluble, 1 (LGALS1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-135

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses LGALS1/Galectin 1 Protein ist gelabelt mit His tag.

Sequenz: Met 1-Asp 135

Produktmerkmale: A DNA sequence encoding the Human Galectin 1 protein (P09382) (Met 1-Asp 135) was expressed with a N-10His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: LGALS1/Galectin 1 (LGALS1) (Lectin, Galactoside-Binding, Soluble, 1 (LGALS1))

Andere Bezeichnung: Galectin-1 (LGALS1 Produkte)

Synonyme: GAL1 Protein, GBP Protein, Galectin-1 Protein, LGAS1 Protein, LGALS1 Protein, MGC64502 Protein, GB10026 Protein, AA410090 Protein, Gal-1 Protein, Galbp Protein, L-14.5 Protein, L14 Protein, Lect14 Protein, galectin-1 Protein, Galaptin Protein, galectin 1 Protein, galectin-1 Protein, lectin, galactoside-binding, soluble, 1 L homeolog Protein, protein enabled Protein, lectin, galactose binding, soluble 1 Protein, LGALS1 Protein, Lgals1 Protein, CC1G_05003 Protein, CC1G_05004 Protein, lgals1.L Protein, LOC408848 Protein

Hintergrund:

Abbreviation: Galectin-1,LGALS1

Target Synonym: Galectin-1,Gal-1,14 kDa Laminin-Binding Protein,HLBP14,14 kDa Lectin,Beta-Galactoside-Binding Lectin L-14-I,Galaptin,HBL,HPL,Lactose-Binding Lectin 1,Lectin Galactoside-Binding Soluble 1,Putative MAPK-Activating Protein PM12,S-Lac Lectin 1,LG

Background: Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state in order to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumour progression including cell adhesion, migration and tumour-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host-pathogen interactions.

Molekulargewicht:

Calculated MW: 14.63 kDa

Observed MW: 15 kDa

UniProt: P09382

Pathways: Carbohydrate Homeostasis