MMP1 Protein (AA 20-469) (His tag)

Produktnummer ABIN7505142

Produktdetails

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 20-469

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses MMP1 Protein ist gelabelt mit His tag.

Sequenz: Phe 20-Asn 469

Produktmerkmale: A DNA sequence encoding the Human MMP1 protein (P03956) (Phe 20-Asn 469) was expressed with a N-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Andere Bezeichnung: MMP1 (MMP1 Produkte)

Synonyme: CLG Protein, CLGN Protein, Mmp1a Protein, CG4859 Protein, Dm1-MMP Protein, Dmel\\CG4859 Protein, MMP-1 Protein, MMP1 Protein, Mmp 1 Protein, dMMP1 Protein, dm1-MMP Protein, dmmp1 Protein, l(2)k04809 Protein, mmp1 Protein, Mmp1 Protein, Mcol-A Protein, Mcola Protein, col4 Protein, mmp18 Protein, Clgn Protein, matrix metallopeptidase 1 Protein, Matrix metalloproteinase 1 Protein, matrix metalloproteinase 1 Protein, matrix metallopeptidase 1 (interstitial collagenase) Protein, matrix metallopeptidase 1a (interstitial collagenase) Protein, matrix metallopeptidase 1 S homeolog Protein, interstitial collagenase Protein, matrix metallopeptidase 8 L homeolog Protein, MMP1 Protein, Mmp1 Protein, RB11133 Protein, Mmp1a Protein, mmp1.S Protein, LOC100727966 Protein, mmp8.L Protein

Hintergrund:

Abbreviation: MMP1

Target Synonym: Interstitial Collagenase,Fibroblast Collagenase,Matrix Metalloproteinase-1,MMP-1,MMP1,CLG

Background: MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. MMP-1 cleaves collagens of types I, II, and III at one site in the helical domain. It also cleaves collagens of types VII and X. In case of HIV infection, MMP1 interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

Molekulargewicht:

Calculated MW: 49.39 kDa

Observed MW: 58 kDa

UniProt: P03956