SMOC2 Protein (AA 229-415) (His tag)

Produktnummer ABIN7505151

Produktdetails

Target: SMOC2 (SPARC Related Modular Calcium Binding 2 (SMOC2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 229-415

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses SMOC2 Protein ist gelabelt mit His tag.

Sequenz: Gln 229-Val 415

Produktmerkmale: A DNA sequence encoding the Human SMOC2 protein (Q9H3U7) (Gln 229-Val 415) was expressed with a N-10His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: SMOC2 (SPARC Related Modular Calcium Binding 2 (SMOC2))

Andere Bezeichnung: SMOC2 (SMOC2 Produkte)

Synonyme: cb488 Protein, wu:fb75d10 Protein, zgc:112171 Protein, SMOC2 Protein, DTDP1 Protein, MST117 Protein, MSTP117 Protein, MSTP140 Protein, SMAP2 Protein, bA270C4A.1 Protein, bA37D8.1 Protein, dJ421D16.1 Protein, 1700056C05Rik Protein, 5430426J21Rik Protein, Smoc2l Protein, SPARC related modular calcium binding 2 Protein, SPARC-related modular calcium-binding protein 2 Protein, smoc2 Protein, SMOC2 Protein, LOC100512748 Protein, Smoc2 Protein

Hintergrund:

Abbreviation: SMOC2

Target Synonym: MST117,MSTP117,MSTP140,Secreted modular calcium binding protein 2,SMAP 2,SMAP-2,Smooth muscle associated protein 2

Background: SMOC-2 (secreted, or SPARC-related, modular calcium-binding protein 2), previously called SMAP2 (smooth muscle-associated protein 2), is a 55 kDa glycoprotein that is a member of the SPARC family of matricellular proteins. The human SMOC-2 cDNA encodes 446 amino acids (aa), including a 21 aa signal sequence, a Kazal-like domain (aa 40 - 84), two thyroglobulin type-1 segments (aa 87 - 153 and 213 - 281) and two EF-hand sequences (aa 347 - 382 and 384 - 419). Of three splice variants, one shows a 13 aa substitution for aa 442 - 446, another shows an 11 aa insertion after Thr170, and a third contains both of these variations. SMOC-2 is widely expressed in the extracellular matrix and appears to have adhesion-related functions. Recombinant bacterially produced human SMOC-1 and SMOC-2 can bind the acute phase protein, C-reactive protein, and the adhesion proteins, fibulin and vitronectin, while keratinocyte SMOC-2 binds integrins alpha v beta 1 and alpha v beta 6. SMOC-2 promotes cell cycle progression by signaling through the integrin-linked kinase (ILK) to upregulate cyclin-D1. When expressed in the endothelial extracellular matrix, it potentiates growth factor-induced angiogenesis. SMOC-2 expression is upregulated during neointima formation, promoting proliferation and migration of vascular smooth muscle. In the skin, it promotes keratinocyte attachment and migration. Since Kazal and thyroglobulin domains are often found in protease inhibitors, SMOC-2 is also proposed to inhibit proteases in the lung and artery.

Molekulargewicht:

Calculated MW: 20.46 kDa

Observed MW: 32 kDa

UniProt: Q9H3U7