CASR Protein (AA 863-1078) (His tag)

Produktnummer ABIN7505157

Produktdetails

Target: CASR (Calcium-Sensing Receptor (CASR))

Protein-Typ: Recombinant

Proteineigenschaft: AA 863-1078

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CASR Protein ist gelabelt mit His tag.

Sequenz: Lys 863-Ser 1078

Produktmerkmale: A DNA sequence encoding the Human CaSR protein (P41180) (Lys 863-Ser 1078) was expressed with N-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: CASR (Calcium-Sensing Receptor (CASR))

Andere Bezeichnung: CaSR (CASR Produkte)

Synonyme: CAR Protein, EIG8 Protein, FHH Protein, FIH Protein, GPRC2A Protein, HHC Protein, HHC1 Protein, HYPOC1 Protein, NSHPT Protein, PCAR1 Protein, CaR Protein, Gprc2a Protein, gprc2a Protein, xV2R F-1 Protein, CASR Protein, calcium sensing receptor Protein, calcium-sensing receptor Protein, calcium-sensing receptor L homeolog Protein, CASR Protein, Casr Protein, casr.L Protein

Hintergrund:

Abbreviation: CaSR

Target Synonym: Ca sensing receptor,Ca2+ sensing receptor 1,CAR,EIG8,Extracellular calcium sensing receptor,FHH,FIH,GPRC2A,HHC1,NSHPT,PCAR 1,PCaR1

Background: CaSR, the extracellular Calcium-Sensing Receptor, is a widely expressed G-protein coupled receptor (GPCR) involved in calcium homeostasis. CaSR operates as a sensor in parathyroid and kidney, and alterations in its activity have been shown to cause thyroid disease in humans. Activation of the receptor in response to extracellular calcium or other ligands causes activation of phospholipase C (PLC), release of IP3 and release of calcium from intracellular stores. Proinflammatory cytokines IL-1β and TNF-α increase CaSR gene expression in human thyroid and kidney cells through activation of the NF-κB pathway, and this pathway may be involved in hypocalcemia often seen in critically ill patients. Elevated calcium concentration and CaSR expression have been linked to proliferation and metastasis of skeletal metastatic prostate cancer cell lines. In intestinal epithelial cells, CaSR is involved in regulation of cyclic nucleotide metabolism and the fluid secretion that results in life-threatening fluid loss in response to intestinal pathogens. The interaction of CaSR with the actin-binding protein filamin may provide scaffolding for the organization of signaling pathways converging on the cytoskeleton, including CaSR-mediated MAPK pathway activation.

Molekulargewicht:

Calculated MW: 23.65 kDa

Observed MW: 35 kDa

UniProt: P41180

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis