Cyclin D3 Protein (CCND3) (AA 1-292) (His tag)

Produktnummer ABIN7505171

Produktdetails

Target: Cyclin D3 (CCND3)

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-292

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Cyclin D3 Protein ist gelabelt mit His tag.

Sequenz: Met 1-Leu 292

Produktmerkmale: A DNA sequence encoding the Human cyclin D3/CCND3 protein (P30281) (Met 1-Leu 292) was expressed with N-His.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Cyclin D3 (CCND3)

Andere Bezeichnung: cyclin D3 (CCND3 Produkte)

Synonyme: zgc:103502 Protein, CCND3 Protein, 9230106B05Rik Protein, AA682053 Protein, AL024085 Protein, AW146355 Protein, C78795 Protein, cyclin D3 Protein, ccnd3 Protein, CCND3 Protein, Ccnd3 Protein

Hintergrund:

Abbreviation: cyclin D3,CCND3

Target Synonym: G1/S-specific cyclin-D3,CyclinD3

Background: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Molekulargewicht:

Calculated MW: 32.01 kDa

Observed MW: 35 kDa

UniProt: P30281

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process