TGFBR3 Protein (AA 526-787) (His tag)

Produktnummer ABIN7505176

Produktdetails

Target: TGFBR3 (Transforming Growth Factor, beta Receptor III (TGFBR3))

Protein-Typ: Recombinant

Proteineigenschaft: AA 526-787

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses TGFBR3 Protein ist gelabelt mit His tag.

Sequenz: Gln 526-Thr 787

Produktmerkmale: A DNA sequence encoding the Human TGFBR3/ Betaglycan protein (Q03167) (Gln 526-Thr 787) was expressed with N-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: TGFBR3 (Transforming Growth Factor, beta Receptor III (TGFBR3))

Andere Bezeichnung: TGFBR3 (TGFBR3 Produkte)

Synonyme: TGFBR3 Protein, DKFZp469I0915 Protein, BGCAN Protein, betaglycan Protein, 1110036H20Rik Protein, AU015626 Protein, AW215636 Protein, TBRIII Protein, transforming growth factor beta receptor 3 Protein, transforming growth factor, beta receptor III Protein, TGFBR3 Protein, tgfbr3 Protein, Tgfbr3 Protein

Hintergrund:

Abbreviation: TGFBR3;Betaglycan

Target Synonym: BGCAN

Background: Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. TGFBR3 is the TGF-β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 knockdown led to focus formation and enhanced expression of CD133, a marker found on prostate cancer stem cells. TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive biology. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.

Molekulargewicht:

Calculated MW: 28.71 kDa

Observed MW: 35 kDa

UniProt: Q03167