RAB5B Protein (AA 1-215) (His tag)

Produktnummer ABIN7505212

Produktdetails

Target: RAB5B (RAB5B, Member RAS Oncogene Family (RAB5B))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-215

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses RAB5B Protein ist gelabelt mit His tag.

Sequenz: Met 1-Asn 215

Produktmerkmale: A DNA sequence encoding the Human RAB5B protein (P61020) (Met 1-Asn 215) was expressed with a C-His,N-His.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: RAB5B (RAB5B, Member RAS Oncogene Family (RAB5B))

Andere Bezeichnung: RAB5B (RAB5B Produkte)

Synonyme: zgc:76978 Protein, C030027M18Rik Protein, RAB5B, member RAS oncogene family Protein, RAB5B, member RAS oncogene family L homeolog Protein, rab5b Protein, LOC613071 Protein, RAB5B Protein, Rab5b Protein, rab5b.L Protein

Hintergrund:

Abbreviation: RAB5B

Target Synonym: Ras-related protein Rab-5B,RAB5B

Background: Antisense inhibition of Rab5b, a gene coding for a small GTPase associated with endocytosis, significantly reduced the mGluR-mediated neuroprotection. Ras-related protein Rab-5B (RAB5B), which is identified by a genome-wide association study as a risk locus for this syndrome, encodes a small GTPase involved in the control of receptor internalization and early endosome fusion. Previous genome-wide sequencing revealed that RAB5B is a susceptible target in patients with polycystic ovary syndrome (PCOS). RAB5A gene was abnormally expressed in luteinized granulosa cells of obese patients with polycystic ovary syndrome, which may help explain high FSHR levels found in this syndrome. RAB5B is directly downregulated by miR-130a-3p. Knockdown of RAB5B also inhibited cell proliferation, migration, and invasion.

Molekulargewicht:

Calculated MW: 23.54 kDa

Observed MW: 30 kDa

UniProt: P61020-1