Vinculin Protein (VCL) (AA 1-650) (His tag)

Produktnummer ABIN7505228

Produktdetails

Target: Vinculin (VCL)

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-650

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Vinculin Protein ist gelabelt mit His tag.

Sequenz: Met 1-Val650

Produktmerkmale: A DNA sequence encoding the Human Vinculin(VCL) protein (P18206) (Met 1-Val650) was expressed with a N-His&C-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Vinculin (VCL)

Andere Bezeichnung: Vinculin (VCL Produkte)

Synonyme: CMD1W Protein, CMH15 Protein, MV Protein, MVCL Protein, VCL Protein, im:6902790 Protein, hm:zehn2160 Protein, DDBDRAFT_0186762 Protein, DDBDRAFT_0232320 Protein, DDB_0186762 Protein, DDB_0232320 Protein, 9430097D22 Protein, AA571387 Protein, AI462105 Protein, AW545629 Protein, CG3299 Protein, CT11081 Protein, Dmel\\CG3299 Protein, Dmvincp Protein, EG:103B4.1 Protein, Vin Protein, Vin2EF Protein, vinc Protein, LOC100228062 Protein, vcl-A Protein, vinculin Protein, vinculin a Protein, vinculin A Protein, Vinculin Protein, vinculin S homeolog Protein, VCL Protein, vcla Protein, vinA Protein, Vcl Protein, Vinc Protein, CpipJ_CPIJ013873 Protein, Bm1_37935 Protein, vcl Protein, vcl.S Protein

Hintergrund:

Abbreviation: Vinculin,VCL

Target Synonym: Vinculin,Metavinculin,VCL,CMD1W,CMH15,HEL114,MV,MVCL

Background: Vinculin is a focal adhesion and cytoskeletal protein that distributed mainly at cell-cell junctions and cell-extracellular matrix (ECM) adhesion that belongs to the Vinculin/α-Catenin family. Vinculin is an Actin-binding protein and component of the Actin-Linking Functional module that senses and feels the mechanical properties of the extracellular environment. Vinculin is also a key factor that couples, transmits, transduces, and regulates mechanical force between the cytoskeleton and adhesion receptors. Vinculin generally forms two structural states, an open (active) and closed (inactive) state, which are controlled by conformational interaction(s) between the head and tail domains. Vinculin is involved in the mechano-chemical signal transmission of cells by binding to a variety of focal adhesion or cytoskeletal proteins, and plays important roles in cell adhesion, extension, motion, proliferation and survival.

Molekulargewicht:

Calculated MW: 71.39 kDa

Observed MW: 60 kDa

UniProt: P18206

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2