MMP16 Protein (AA 151-450) (His tag)

Produktnummer ABIN7505288

Produktdetails

Target: MMP16 (Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16))

Protein-Typ: Recombinant

Proteineigenschaft: AA 151-450

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses MMP16 Protein ist gelabelt mit His tag.

Sequenz: Ala 151-Lys 450

Produktmerkmale: A DNA sequence encoding the Human MMP16 protein (P51512) (Ala 151-Lys 450) was expressed with a N-His&C-His.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: MMP16 (Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16))

Andere Bezeichnung: MMP16 (MMP16 Produkte)

Synonyme: MT3-MMP Protein, Mt3mmp Protein, Mt3-mmp Protein, C8orf57 Protein, MMP-X2 Protein, MT-MMP2 Protein, MT-MMP3 Protein, matrix metallopeptidase 16 Protein, Mmp16 Protein, MMP16 Protein

Hintergrund:

Abbreviation: MMP16

Target Synonym: Matrix metalloproteinase-16,MMP16,

Background: Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix (ECM). MMP-16 (MT3-MMP) is found in brain, lung, placenta, smooth muscle cells, and malignant tumor tissues including oral melanoma and renal carcinoma . MMP-16 has been shown to activate proMMP-2 and degrade various ECM components including native collagens. MMP-16 has been proposed to possess the potential to directly enhance the growth and invasiveness of cells in vivo, two critical processes for development and carcinogenesis . Structurally, MMP-16 consists of the following domains: a pro domain containing the furin cleavage site, a catalytic domain containing the zinc-binding site, a hinge region, a hemopexin-like domain, a transmembrane domain, and a cytoplamasic tail . The structure of the catalytic domain in complex with a hydroxamate inhibitor has been solved . The rhMMP-16PC consists of the pro and catalytic domains, which can be activated by treatment with furin.

Molekulargewicht:

Calculated MW: 32.89 kDa

Observed MW: 35 kDa

UniProt: P51512