MCM8 Protein (AA 1-250) (His tag)

Produktnummer ABIN7505291

Produktdetails

Target: MCM8 (Minichromosome Maintenance Deficient 8 (MCM8))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-250

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses MCM8 Protein ist gelabelt mit His tag.

Sequenz: Met 1-Ser 250

Produktmerkmale: A DNA sequence encoding the Human MCM8 protein (Q9UJA3) (Met 1-Ser 250) was expressed with a C-His,N-His.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: MCM8 (Minichromosome Maintenance Deficient 8 (MCM8))

Andere Bezeichnung: MCM8 (MCM8 Produkte)

Synonyme: C20orf154 Protein, dJ967N21.5 Protein, 5730432L01Rik Protein, minichromosome maintenance 8 homologous recombination repair factor Protein, minichromosome maintenance 8 homologous recombination repair factor L homeolog Protein, MCM8 Protein, Mcm8 Protein, mcm8.L Protein

Hintergrund:

Abbreviation: MCM8

Target Synonym: DNA helicase MCM8,MCM8,Minichromosome maintenance 8

Background: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.

Molekulargewicht:

Calculated MW: 27.39 kDa

Observed MW: 35 kDa

UniProt: Q9UJA3-1

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA