Cytokeratin 19 Protein (AA 80-400) (His tag)

Produktnummer ABIN7505316

Produktdetails

Target: Cytokeratin 19 (KRT19) (Keratin 19 (KRT19))

Protein-Typ: Recombinant

Proteineigenschaft: AA 80-400

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Cytokeratin 19 Protein ist gelabelt mit His tag.

Sequenz: Glu 80-Leu 400

Produktmerkmale: A DNA sequence encoding the Human Cytokein19 protein (P08727) (Glu 80-Leu 400) was expressed with a N-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Cytokeratin 19 (KRT19) (Keratin 19 (KRT19))

Abstract: KRT19 Produkte

Synonyme: CK19 Protein, K19 Protein, K1CS Protein, AI663979 Protein, EndoC Protein, Krt-1.19 Protein, Krt1-19 Protein, Ka19 Protein, k19 Protein, ck19 Protein, k1cs Protein, krt9 Protein, krt15 Protein, MGC76282 Protein, GK-19 Protein, MGC83069 Protein, KRT19 Protein, keratin 19 Protein, keratin 19 L homeolog Protein, keratin, type I cytoskeletal 19 Protein, KRT19 Protein, Krt19 Protein, krt19 Protein, krt19.L Protein, LOC100344434 Protein, LOC101117946 Protein

Hintergrund:

Abbreviation: Cytokein19

Target Synonym: Keratin,type I cytoskeletal 19,KRT19,Keratin-19 (K19)

Background: Cytokeratin 19 (Keratin, type I cytoskeletal 19, also KRT-19, CK19 and Keratin-19) is a 40-45 kDa, acidic Class I keratin member of the intermediate filament family of proteins. Individual keratins are always expressed in tandem with a second keratin, and these are found in all epithelial cells. The class I KRT-19 heterodimerizes/polymerizes with 50-52 kDa class II KRT-8 (plus KRT-5 and -7) to form 8-10 nm filaments in epidermal stem cells, secretory gland (sweat, mammary, bile duct) simple epithelium, and neuroendocrine epidermal Merkel cells. It may represent a viable marker for skin stem cells. In skin, Cytokeratin 19 forms filaments in the fetal epithelium, and then progressively decreases with age, being virtually absent by age 17. Human Cytokeratin 19 is 400 amino acids (aa) in length. It contains an N-terminal "head" region (aa 1-79) and a subsequent "rod" region (aa 80-387), but is absent a typical C-terminal tail region. Cytokeratin 19 possesses at least 5 utilized phosphorylation sites plus one acetylated Lys residue. Based on other keratins, and the presence of an Asp at position 238, there may be caspase cleavage-generated isoforms. Full length human Cytokeratin 19 (aa 2-400) shares 82 % aa sequence identity with mouse Cytokeratin 19.

Molekulargewicht:

Calculated MW: 35.2 kDa

Observed MW: 38 kDa

UniProt: P08727