COMP Protein (AA 22-240) (GST-His-Tag)

Produktnummer ABIN7505321

Produktdetails

Target: COMP (Cartilage Oligomeric Matrix Protein (COMP))

Protein-Typ: Recombinant

Proteineigenschaft: AA 22-240

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses COMP Protein ist gelabelt mit GST-His-Tag.

Sequenz: Gly 22-His 240

Produktmerkmale: A DNA sequence encoding the Human COMP protein (P49747) (Gly 22-His 240) was expressed with a N-GST&C-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: COMP (Cartilage Oligomeric Matrix Protein (COMP))

Andere Bezeichnung: COMP (COMP Produkte)

Synonyme: COMP Protein, EDM1 Protein, EPD1 Protein, MED Protein, PSACH Protein, THBS5 Protein, TSP5 Protein, cartilage oligomeric matrix protein Protein, COMP Protein, sce3551 Protein, CJA_1292 Protein, Comp Protein

Hintergrund:

Abbreviation: COMP

Target Synonym: EDM1,EPD1,MED,PSACH,THBS5

Background: Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and function. It is suggested to play a role in cell growth and development, and recent studies have revealed the possible mechanism that it protects cells against death by elevating members of the IAP (inhibitor of apoptosis protein) family of survival proteins. Mutations in COMP cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1), and up-regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas.

Molekulargewicht:

Calculated MW: 48.98 kDa

Observed MW: 50 kDa

UniProt: P49747