PSMA Protein (AA 45-335) (His tag)

Produktnummer ABIN7505438

Produktdetails

Target: PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 45-335

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses PSMA Protein ist gelabelt mit His tag.

Sequenz: Lys 45-Phe 335

Produktmerkmale: A DNA sequence encoding the mouse PSMA / FOLH1 protein (O35409) (Lys 45-Phe 335) was expressed with N-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))

Andere Bezeichnung: PSMA (FOLH1 Produkte)

Synonyme: FGCP Protein, FOLH Protein, GCP2 Protein, GCPII Protein, NAALAD1 Protein, NAALAdase Protein, PSM Protein, PSMA Protein, mGCP Protein, mopsm Protein, Naalad Protein, putative N-acetylated-alpha-linked acidic dipeptidase Protein, folate hydrolase 1B Protein, folate hydrolase 1 Protein, folate hydrolase (prostate-specific membrane antigen) 1 Protein, LOC451185 Protein, FOLH1B Protein, FOLH1 Protein, Folh1 Protein

Hintergrund:

Abbreviation: PSMA;FOLH1

Target Synonym: Glutamate carboxypeptidase 2;Folh1;Folate hydrolase 1;Folylpoly-gamma-glutamate carboxypeptidase (FGCP);Glutamate carboxypeptidase II (GCPII);Membrane glutamate carboxypeptidase (mGCP);N-acetylated-alpha-linked acidic dipeptidase I (NAALADase I)

Background: Glutamate carboxypeptidase 2, also known as Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, Prostate-specific membrane antigen, GCPII, PSMA, FOLH1, and NAALAD1, is a single-pass type I I membrane protein which belongs to the peptidase M28 family and M28B subfamily. FOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, brain (at protein level), and the capillary endothelium of a variety of tumors. FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity. It has a preference for tri-alpha-glutamate peptides. Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease, neural tube defects, and cognitive deficits. FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.

Molekulargewicht:

Calculated MW: 31.9 kDa

Observed MW: 38 kDa

UniProt: O35409