IGFBP2 Protein (AA 35-305) (His tag)

Produktnummer ABIN7505441

Produktdetails

Target: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 35-305

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses IGFBP2 Protein ist gelabelt mit His tag.

Sequenz: Glu 35-Gln 305

Produktmerkmale: A DNA sequence encoding the Mouse IGFBP-2 / IGFBP2 protein (P47877) (Glu 35-Gln 305) was expressed with N-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Andere Bezeichnung: IGFBP-2 (IGFBP2 Produkte)

Synonyme: IBP2 Protein, IGF-BP53 Protein, AI255832 Protein, IBP-2 Protein, Igfbp-2 Protein, mIGFBP-2 Protein, IGFBP-2 Protein, ILGFBPA Protein, pIGFBP-2 Protein, igfbp2 Protein, MGC65741 Protein, MGC76823 Protein, MGC174445 Protein, IGFBP2 Protein, ibp2 Protein, igf-bp53 Protein, igfbp2a Protein, si:ch211-2k18.3 Protein, insulin like growth factor binding protein 2 Protein, insulin-like growth factor binding protein 2 Protein, insulin-like growth factor binding protein 2a Protein, insulin-like growth factor binding protein 2b Protein, IGFBP2 Protein, Igfbp2 Protein, igfbp2a Protein, igfbp2 Protein, igfbp2b Protein

Hintergrund:

Abbreviation: IGFBP-2,IGFBP2

Target Synonym: Insulin-like growth factor-binding protein 2, Igfbp2,IBP-2,IGF-binding protein 2,IGFBP-2,mIGFBP-2

Background: IGFBP-2, also known as IGFBP2, is a insulin-like growth factor-binding protein (IGFBP). IGFBPs prolong the half-life of the IGFs , control bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to -6) have been identified. The six IGFBPs are structurally related but encoded by distinct genes. IGFBPs have a high affinity for IGFs. Some members of the IGFBP family have been consistently shown to inhibit IGF actions by preventing them from gaining access to the IGF receptors, while others potentiate IGF actions by facilitating the ligand-receptor interaction. IGFBP-2 is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to a potential involvement of IGFBP-2 in tumorigenesis. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. It inhibits IGF-mediated growth and developmental rates.

Molekulargewicht:

Calculated MW: 29.7 kDa

Observed MW: 39 kDa

UniProt: P47877

Pathways: Myometrial Relaxation and Contraction, Growth Factor Binding, Activated T Cell Proliferation