Occludin Protein (OCLN) (AA 266-522) (His tag)

Produktnummer ABIN7505510

Produktdetails

Target: Occludin (OCLN)

Protein-Typ: Recombinant

Proteineigenschaft: AA 266-522

Spezies: Ratte

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Occludin Protein ist gelabelt mit His tag.

Sequenz: Lys266-Thr522

Produktmerkmale: A DNA sequence encoding the Rat OCLN protein (Q6P6T5) (Lys266-Thr522) was expressed with a N-His .

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Occludin (OCLN)

Andere Bezeichnung: Occludin (OCLN Produkte)

Synonyme: AI503564 Protein, Ocl Protein, ocln Protein, oclnb Protein, tpmt Protein, OCLN Protein, wu:fd23h10 Protein, wu:fi13c01 Protein, zgc:113992 Protein, zgc:56359 Protein, BLCPMG Protein, occludin Protein, occludin S homeolog Protein, occludin a Protein, Ocln Protein, OCLN Protein, ocln.S Protein, ocln Protein, oclna Protein

Hintergrund:

Abbreviation: Occludin,OCLN

Target Synonym: Occludin,OCLN_RAT,

Background: Rat Occludin is a 523 amino acid (aa), predicted molecular weight 59 kDa integral membrane protein that localizes within tight junctions of epithelial and endothelial cells. May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. May be involved in the organization of actin in endothelial cells. Defects in OCLN are the cause of band-like calcification with simplified gyration and polymicrogyria (BLCPMG), also known as pseudo-TORCH syndrome. BLCPMG is a neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay.

Molekulargewicht:

Calculated MW: 28.16 kDa

Observed MW: 40 kDa

UniProt: Q6P6T5

Pathways: Cell-Cell Junction Organization, Hepatitis C