Caspase 3 Protein (CASP3) (AA 29-175) (His tag)
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- Target Alle Caspase 3 (CASP3) Proteine anzeigen
- Caspase 3 (CASP3)
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 29-175
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Spezies
- Ratte
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses Caspase 3 Protein ist gelabelt mit His tag.
- Sequenz
- Ser 29-Asp 175
- Produktmerkmale
- A DNA sequence encoding the Rat CASP3 protein (P55213) (Ser 29-Asp 175) was expressed with a N-His tag.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CASP3 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Haltbarkeit
- 12 months
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- Target
- Caspase 3 (CASP3)
- Andere Bezeichnung
- CASP3 (CASP3 Produkte)
- Synonyme
- CPP32 Protein, CPP32B Protein, SCA-1 Protein, A830040C14Rik Protein, AC-3 Protein, Apopain Protein, CC3 Protein, Caspase-3 Protein, Lice Protein, Yama Protein, mldy Protein, xcpp32 Protein, casp3 Protein, zgc:100890 Protein, CASP-3 Protein, caspase-3 Protein, caspase 3 Protein, caspase 3 S homeolog Protein, caspase 3, apoptosis-related cysteine peptidase a Protein, caspase 3, apoptosis-related cysteine peptidase Protein, CASP3 Protein, Casp3 Protein, casp3.S Protein, casp3a Protein
- Hintergrund
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Abbreviation: CASP3
Target Synonym: CASP-3,CASP3,CASP3,Casp3a,Caspase 3,Caspase 3,Casp3,Cpp32
Background: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage .Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes .Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME).Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface.
- Molekulargewicht
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Calculated MW: 16.06 kDa
Observed MW: 20 kDa
- UniProt
- P55213
- Pathways
- Apoptose, Caspase Kaskade in der Apoptose, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
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