Adrenomedullin Protein (ADM) (AA 21-185) (His tag)

Produktnummer ABIN7505525

Produktdetails

Target: Adrenomedullin (ADM)

Protein-Typ: Recombinant

Proteineigenschaft: AA 21-185

Spezies: Ratte

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Adrenomedullin Protein ist gelabelt mit His tag.

Sequenz: Thr 21-Leu 185

Produktmerkmale: A DNA sequence encoding the Rat Adrenomedullin/ADM protein (P43145) (Thr 21-Leu 185) was expressed with a N-His tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Adrenomedullin (ADM)

Andere Bezeichnung: Adrenomedullin (ADM Produkte)

Synonyme: ADM Protein, Ap Protein, H39316 Protein, RATAP Protein, AM Protein, adrenomedullin Protein, ADM Protein, adm Protein, Adm Protein

Substanzklasse: Hormone

Hintergrund:

Abbreviation: Adrenomedullin,ADM

Target Synonym: ADM precursor,Adrenomedullin,PAMP,Preproadrenomedullin,ProAM N terminal 20 peptide,ProAM N20

Background: Adrenomedullin (ADM, also AM) is a secreted, monomeric, 6 kDa member of the Adrenomedullin family of molecules. It is widely expressed, being found in smooth muscle cells, endothelium, adrenal medulla chromaffin cells, fibroblasts and keratinocytes. ADM has multiple functions, including vasodilation, the maintenance of vascular integrity, and the suppression of inflammatory mediator secretion. The ADM preproprecursor is 185 amino acids (aa) in length. It contains a 21 aa signal sequence, a processed 20 aa peptide termed PAMP (aa 22-41), an N-terminal propeptide (aa 45-91), the ADM precursor (amidation is required for maturation) (aa 94 143), and a C-terminal propeptide (aa 150-185). The ADM precursor with a terminal Gly147 circulates naturally with bioactive, mature amidated ADM (aa 94 143).

Molekulargewicht:

Calculated MW: 18.04 kDa

Observed MW: 25 kDa

UniProt: P43145

Pathways: Hormone Transport, Hormone Activity, C21-Steroid Hormone Metabolic Process, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Tube Formation