LILRA5 Protein (AA 42-268) (His tag)

Produktnummer ABIN7505590

Produktdetails

Target: LILRA5 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5 (LILRA5))

Protein-Typ: Recombinant

Proteineigenschaft: AA 42-268

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses LILRA5 Protein ist gelabelt mit His tag.

Sequenz: Gly42-Arg268

Produktmerkmale: Recombinant Human LILRA5 Member 5 is produced by our Mammalian expression system and the target gene encoding Gly42-Arg268 is expressed with a 6His tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: <1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: LILRA5 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5 (LILRA5))

Andere Bezeichnung: LILRA5 (LILRA5 Produkte)

Synonyme: CD85 Protein, CD85F Protein, ILT-11 Protein, ILT11 Protein, LILRB7 Protein, LIR-9 Protein, LIR9 Protein, E030017K20 Protein, EG232801 Protein, Gm4878 Protein, Lilrc1 Protein, leukocyte immunoglobulin like receptor A5 Protein, leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 Protein, LILRA5 Protein, Lilra5 Protein

Hintergrund:

Abbreviation: LILRA5

Target Synonym: Leukocyte immunoglobulin-like receptor subfamily A member 5,CD85 antigen-like family member F,Immunoglobulin-like transcript 11,ILT-11,Leukocyte immunoglobulin-like receptor 9,LIR-9,CD85f,LILRA5,LILRB7,CD85F,ILT11,LILRB7,LIR-9,LIR9

Background: Leukocyte Immunoglobulin-like Receptor Subfamily A Member 5(LILRA5)is a member of the leukocyte immunoglobulin-like receptors (LILR), comprise a family of activating and inhibitory type immunoreceptors. LILRA5 consists of a 227 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 10 aa cytoplasmic tail. The ECD contains two Ig-like domains and the transmembrane segment contains a positively charged aspartic acid residue which may mediate its association with the signaling molecule, FcR common gamma chain. LILRA5 is expressed by monocytes, macrophages, and neutrophils. Cross-linking of LILRA5 on monocytes induces the expression of pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) as well as the anti-inflammatory IL-10. It can be detected in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Crosslink of ILT-11 on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses.

Molekulargewicht:

Calculated MW: 26.1 kDa

Observed MW: 35-40 kDa

UniProt: A6NI73