FGF18 Protein (AA 1-207) (His tag)

Produktnummer ABIN7505614

Produktdetails

Target: FGF18 (Fibroblast Growth Factor 18 (FGF18))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-207

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses FGF18 Protein ist gelabelt mit His tag.

Sequenz: Met1-Ala207

Produktmerkmale: A DNA sequence encoding the Human FGF18 protein (O76093) (Met1-Ala207) was expressed with a C-His.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: FGF18 (Fibroblast Growth Factor 18 (FGF18))

Andere Bezeichnung: FGF-18 (FGF18 Produkte)

Synonyme: FGF-18 Protein, ZFGF5 Protein, D130055P09Rik Protein, fgf18 Protein, FGF18 Protein, fgf18l Protein, fibroblast growth factor 18 Protein, fibroblast growth factor 18a Protein, fibroblast growth factor 18b Protein, FGF18 Protein, Fgf18 Protein, fgf18a Protein, Tsp_09844 Protein, fgf18b Protein

Hintergrund:

Abbreviation: FGF-18

Target Synonym: Fibroblast growth factor 18,FGF-18,zFGF5,FGF18,UNQ420,PRO856

Background: Fibroblast growth factor 18 (FGF18) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that FGF18 is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Experiment datas identified FGF18 as a selective ligand for FGFR3 in limb bud mesenchymal cells, which suppressed proliferation and promoted their differentiation and production of cartilage matrix. FGF18 appears to regulate cell proliferation and differentiation positively in osteogenesis and negatively in chondrogenesis.

Molekulargewicht:

Calculated MW: 22.66 kDa

Observed MW: 32 kDa

UniProt: O76093

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung