F13B Protein (AA 1-661) (His tag)

Produktnummer ABIN7505637

Produktdetails

Target: F13B (Coagulation Factor 13, B Polypeptide (F13B))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-661

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses F13B Protein ist gelabelt mit His tag.

Sequenz: Met1-Thr661

Produktmerkmale: A DNA sequence encoding the Human F13B protein (P05160) (Met1-Thr661) was expressed with a C-His.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: F13B (Coagulation Factor 13, B Polypeptide (F13B))

Andere Bezeichnung: Coagulation Factor XIII B chain (F13B Produkte)

Synonyme: F13B Protein, coagulation factor XIII B chain Protein, LOC100347263 Protein

Hintergrund:

Abbreviation: F13B

Target Synonym: Coagulation factor 13,Coagulation factor XIII,FXIIIB

Background: Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 10 Sushi ( CCP / SCR ) domains. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Factor XIII acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Defects in F13B are the cause of factor XIII subunit B deficiency ( FA13BD ) which is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.

Molekulargewicht:

Calculated MW: 72.6 kDa

Observed MW: 80 kDa

UniProt: P05160