Glucuronidase beta Protein (AA 1-651) (His tag)

Produktnummer ABIN7505644

Produktdetails

Target: Glucuronidase beta (GUSB) (Glucuronidase, beta (GUSB))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-651

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Glucuronidase beta Protein ist gelabelt mit His tag.

Sequenz: Met1-Thr651

Produktmerkmale: A DNA sequence encoding the Human GUSβ protein (P08236) (Met1-Thr651) was expressed with a C-His.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Glucuronidase beta (GUSB) (Glucuronidase, beta (GUSB))

Andere Bezeichnung: Beta-glucuronidase (GUSB Produkte)

Synonyme: GUSB Protein, beta-GUS Protein, gus Protein, BG Protein, MPS7 Protein, AI747421 Protein, Gur Protein, Gus Protein, Gus-r Protein, Gus-s Protein, Gus-t Protein, Gus-u Protein, Gut Protein, asd Protein, g Protein, Ac2-223 Protein, si:ch211-160e1.7 Protein, si:ct573103.7 Protein, glucuronidase beta Protein, beta-D-glucuronidase Protein, beta-glucuronidase Protein, beta glucuronidase Protein, glucuronidase, beta Protein, GUSB Protein, bglR Protein, SSO_RS14735 Protein, Glu Protein, Gusb Protein, gusb Protein

Hintergrund:

Abbreviation: Beta-glucuronidase,GUSB

Target Synonym: Beta-glucuronidase,EC 3.2.1.31,Beta-G1,GUSB

Background: Human beta -Glucuronidase (EC 3.2.1.31) encoded by the GUSB gene is a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans that include heparan sulfate, chondroitin sulfate and hyaluronan. The enzyme is only active on the glucuronic acid of the non-reducing end. The native protein has been reported as a tetrameric glycoprotein composed of identical subunits. Mutations in the GUSB gene are linked to mucopolysaccharidosis type VII. Accumulation of partially degraded glycosaminoglycans, with glucuronic acid residues at the non-reducing termini, are usually found in the lysosomes of patients with the disease. It has also been reported that this enzyme may contribute to the depletion of chondroitin from cartilage and thereby facilitate the damage of joints in rheumatoid arthritis.

Molekulargewicht:

Calculated MW: 71.5 kDa

Observed MW: 80 kDa

UniProt: P08236

Pathways: Glycosaminoglycan Metabolic Process