CD59 Protein (CD59) (AA 1-101) (His tag)
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- Target Alle CD59 Proteine anzeigen
- CD59
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 1-101
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses CD59 Protein ist gelabelt mit His tag.
- Sequenz
- Met1-Glu101
- Produktmerkmale
- A DNA sequence encoding the Human CD59 protein (P13987) (Met1-Glu101) was expressed with a C-His.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CD59 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Haltbarkeit
- 12 months
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- Target
- CD59
- Andere Bezeichnung
- CD59 (CD59 Produkte)
- Synonyme
- 16.3A5 Protein, 1F5 Protein, EJ16 Protein, EJ30 Protein, EL32 Protein, G344 Protein, HRF-20 Protein, HRF20 Protein, MAC-IP Protein, MACIF Protein, MEM43 Protein, MIC11 Protein, MIN1 Protein, MIN2 Protein, MIN3 Protein, MIRL Protein, MSK21 Protein, p18-20 Protein, Cd59a Protein, Cd59b Protein, MACIP Protein, CD59 molecule (CD59 blood group) Protein, CD59 molecule Protein, CD59 Protein, Cd59 Protein
- Hintergrund
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Abbreviation: CD59
Target Synonym: 16.3A5,1F5,1F5,EJ16,EJ30,EL32,FLJ38134,FLJ92039,G344,HRF 20,Ly 6
Background: CD59 glycoprotein, also known as 20 kDa homologous restriction factor, HRF20, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).
- Molekulargewicht
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Calculated MW: 11 kDa
Observed MW: 15 kDa
- UniProt
- P13987
- Pathways
- Komplementsystem
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