WISP1 Protein (AA 1-367) (His tag)

Produktnummer ABIN7505655

Produktdetails

Target: WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-367

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses WISP1 Protein ist gelabelt mit His tag.

Sequenz: Met1-Asn367

Produktmerkmale: A DNA sequence encoding the Human WISP1 protein (O95388) (Met1-Asn367) was expressed with a C-His.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))

Andere Bezeichnung: WISP1 (WISP1 Produkte)

Synonyme: CCN4 Protein, WISP1c Protein, WISP1i Protein, WISP1tc Protein, WISP-1 Protein, WISP1 Protein, si:ch211-38f10.2 Protein, AW146261 Protein, Elm1 Protein, zgc:172276 Protein, WNT1 inducible signaling pathway protein 1 Protein, WNT1 inducible signaling pathway protein 1a Protein, WNT1-inducible-signaling pathway protein 1-like Protein, WNT1 inducible signaling pathway protein 1b Protein, WISP1 Protein, wisp1a Protein, Wisp1 Protein, LOC100627044 Protein, wisp1b Protein

Hintergrund:

Abbreviation: WISP1

Target Synonym: CCN family member 4,WNT1-inducible-signaling pathway protein 1,WISP-1,Wnt-1-induced secreted protein,WISP1,CCN4

Background: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma.

Molekulargewicht:

Calculated MW: 40.26 kDa

Observed MW: 60 kDa

UniProt: O95388

Pathways: WNT Signalweg, Growth Factor Binding