IGHG4 Protein (AA 99-327) (His tag,Fc Tag)

Produktnummer ABIN7505663

Produktdetails

Target: IGHG4 (Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4))

Protein-Typ: Recombinant

Proteineigenschaft: AA 99-327

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IGHG4 Protein ist gelabelt mit His tag,Fc Tag.

Sequenz: Glu99-Lys327

Produktmerkmale: A DNA sequence encoding the Human IgG4 protein (P01861) (Glu99-Lys327) was expressed with a C-His.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: IGHG4 (Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4))

Andere Bezeichnung: IGHG4 (IGHG4 Produkte)

Synonyme: immunoglobulin heavy constant gamma 4 (G4m marker) Protein, IGHG4 Protein

Hintergrund:

Abbreviation: IgG4-Fc

Target Synonym: Ig gamma-4 chain C region,IgG4 Fc,IGHG4

Background: SCN3B (sodium channel, voltage-gated, type III, beta ,human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B family. It contains 1 Ig-like C2-type (immunoglobulin-like) domain. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. SCN3B gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. Defects in SCN3B are the cause of Brugada syndrome type 7. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram. It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.

Molekulargewicht:

Calculated MW: 25.08 kDa

Observed MW: 35 kDa

UniProt: P01861