IGFBP7 Protein (AA 1-282) (His tag)

Produktnummer ABIN7505664

Produktdetails

Target: IGFBP7 (Insulin-Like Growth Factor Binding Protein 7 (IGFBP7))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-282

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IGFBP7 Protein ist gelabelt mit His tag.

Sequenz: Met1-Leu282

Produktmerkmale: A DNA sequence encoding the Human IGFBP-7 protein (Q16270) (Met1-Leu282) was expressed with a C-His.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: IGFBP7 (Insulin-Like Growth Factor Binding Protein 7 (IGFBP7))

Andere Bezeichnung: IGFBP-7 (IGFBP7 Produkte)

Synonyme: zgc:85888 Protein, AGM Protein, FSTL2 Protein, IBP-7 Protein, IGFBP-7 Protein, IGFBP-7v Protein, IGFBPRP1 Protein, MAC25 Protein, PSF Protein, RAMSVPS Protein, TAF Protein, Fstl2 Protein, Mac25 Protein, insulin like growth factor binding protein 7 Protein, insulin-like growth factor binding protein 7 Protein, IGFBP7 Protein, igfbp7 Protein, Igfbp7 Protein

Hintergrund:

Abbreviation: IGFBP-7

Target Synonym: Insulin-like growth factor-binding protein 7,IGFBP7,IGF-binding protein 7,IGFBP-rP1,MAC25 protein,Tumor-derived adhesion factor,TAF

Background: Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. Human and mouse IGFBP7 are highly homologous and share 94 % aa sequence identity. It is expressed in many normal tissues and in cancer cells. It is abundantly expressed in high endothelial venules (HEVs) of blood vessels in the secondary lymphoid tissues. It binds IGF and insulin with very low affinity and has been shown to enhance the mitogenic actions of IGF and insulin. IGFBP7 also has IGF/insulin-independent activities. It interacts with heparan sulfate proteoglycans, type IV collagen, and specific chemokines. It supports weak cell adhesion, promotes cell spreading on type IV collagen, and stimulates the production of the potent vasodilator PGI2. It modulates tumor cell growth and has also been implicated in angiogenesis.

Molekulargewicht:

Calculated MW: 30.91 kDa

Observed MW: 32 kDa

UniProt: Q16270

Pathways: Growth Factor Binding