Fetuin A Protein (AA 1-367) (His tag)

Produktnummer ABIN7505670

Produktdetails

Target: Fetuin A (AHSG) (alpha-2-HS-Glycoprotein (AHSG))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-367

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Fetuin A Protein ist gelabelt mit His tag.

Sequenz: Met1-Val367

Produktmerkmale: A DNA sequence encoding the Human FETUA protein (P02765) (Met1-Val367) was expressed with a C-His.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Fetuin A (AHSG) (alpha-2-HS-Glycoprotein (AHSG))

Andere Bezeichnung: Fetuin-A (AHSG Produkte)

Synonyme: ahs Protein, a2hs Protein, hsga Protein, fetua Protein, wu:fb63g02 Protein, zgc:103687 Protein, AHSG Protein, MGC116429 Protein, A2HS Protein, AHS Protein, FETUA Protein, HSGA Protein, Aa2-066 Protein, pp63 Protein, alpha-2-HS-glycoprotein Protein, alpha 2-HS glycoprotein Protein, alpha-2-HS-glycoprotein 1 Protein, alpha-2-HS-glycoprotein L homeolog Protein, Cphamn1_1981 Protein, AHSG Protein, ahsg Protein, ahsg1 Protein, ahsg.L Protein, Ahsg Protein

Hintergrund:

Abbreviation: Fetuin-A,AHSG

Target Synonym: Alpha-2-HS-Glycoprotein,Alpha-2-Z-Globulin,Ba-Alpha-2-Glycoprotein,Fetuin-A,AHSG,FETUA

Background: Fetuin-A, also known as Alpha-2-HS-Glycoprotein (AHSG), belongs to the Fetuin family, is a plasma binding protein, and is more abundant in fetal than adult blood. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuins are carrier proteins like albumin. Fetuin-A forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus Fetuin-A is a potent inhibitor of pathological calcification. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the cell-dependent process of osteogenesis. The low circulating fetuin-A levels are associated with a greater prevalence and/or severity of Vascular calcification (VC) and increased risk for all-cause and cardiovascular mortality. However, high circulating fetuin-A levels appear to induce insulin resistance and, in non-dialyzed subjects with diabetic nephropathy, are directly related to VC burden. The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality. Additionally, Human fetuin-A is a negative acute phase protein involved in inflammatory diseases, thus being a potential physiological regulator of meprin activity. Fetuin-A is a broad-range protease inhibitor. Fetuin-A and cystatin C as endogenous proteolytic regulators of meprin activity broadens our understanding of the proteolytic network in plasma.

Molekulargewicht:

Calculated MW: 40.26 kDa

Observed MW: 58 kDa

UniProt: P02765