SERPINA6 Protein (AA 1-396) (His tag)
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- Target Alle SERPINA6 Proteine anzeigen
- SERPINA6 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 1-396
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Spezies
- Ratte
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses SERPINA6 Protein ist gelabelt mit His tag.
- Sequenz
- Met1-Ala396
- Produktmerkmale
- A DNA sequence encoding the Rat CBG protein (P31211) (1-396) was expressed with a C-His.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product SERPINA6 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Haltbarkeit
- 12 months
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- Target
- SERPINA6 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6))
- Andere Bezeichnung
- Serpin A6 (SERPINA6 Produkte)
- Synonyme
- ep45-A Protein, SERPINA6 Protein, AI265318 Protein, AV104445 Protein, Cbg Protein, CBG Protein, serpin family A member 6 Protein, serpin family A member 6 L homeolog Protein, corticosteroid-binding globulin Protein, serine (or cysteine) peptidase inhibitor, clade A, member 6 Protein, SERPINA6 Protein, serpina6.L Protein, LOC490838 Protein, Serpina6 Protein
- Hintergrund
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Abbreviation: Serpin A6,CBG
Target Synonym: Corticosteroid-binding globulin,CBG,Serpin A6,Transcortin,Serpina6,Cbg
Background: Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90 % of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
- Molekulargewicht
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Calculated MW: 43.45 kDa
Observed MW: 60 kDa
- UniProt
- P31211
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