FGF23 Protein (His tag)

Produktnummer ABIN7520002

Produktdetails

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses FGF23 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant human FGF-23/Fibroblast growth factor 23 Protein

Sequenz: YPNASPLLGS SWGGLIHLYT ATARNSYHLQ IHKNGHVDGA PHQTIYSALM IRSEDAGFVV ITGVMSRRYL CMDFRGNIFG SHYFDPENCR FQHQTLENGY DVYHSPQYHF LVSLGRAKRA FLPGMNPPPY SQFLSRRNEI PLIHFNTPIP RRHTRSAEDD SERDPLNVLK PRARMTPAPA SCSQELPSAE DNSPMASDPL GVVRGGRVNT HAGGTGPEGC RPFAKFI

Spezifität: Tyr25-Ile251

Reinheit: > 97 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: < 0.1EU/μg

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Konzentration: 0.3 mg/mL

Buffer: Lyophilized from a 0.22 μm filtered solution of 20 mM MOPS,150 mM NaCl,5 mM EDTA,2 mM DTT, pH 7.4

Konservierungsmittel: Dithiothreitol (DTT)

Vorsichtsmaßnahmen: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Antigendetails

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Andere Bezeichnung: FGF-23/Fibroblast growth factor 23 (FGF23 Produkte)

Synonyme: FGF23 Protein, ADHR Protein, FGFN Protein, HPDR2 Protein, HYPF Protein, PHPTC Protein, fibroblast growth factor 23 Protein, fgf23 Protein, FGF23 Protein, Fgf23 Protein

Hintergrund:

Description: Fibroblast growth factor 23 (FGF23) is is an endocrine member of the family of FGFs and mainly produced in the bone and, upon secretion, forms a complex with a FGF receptor and coreceptor αKlotho. FGF23 can exert several endocrine functions, such as acting as a hormone on the kidney, stimulating phosphate excretion and suppressing formation of 1,25(OH)2D3, active vitamin D. Moreover, it has paracrine activities on several cell types, including neutrophils and hepatocytes. FGF23 and phosphate have been revealed to be factors relevant in cancer. FGF23 is particularly significant for those forms of cancer primarily affecting bone (e.g., multiple myeloma) or characterized by bone metastasis.

Name: ADHR, FGFN, HYPF, HFTC2, HPDR2, PHPTC

Gen-ID: 8074

UniProt: Q9GZV9

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Negative Regulation of Hormone Secretion