FLT4 Protein (His tag)

Produktnummer ABIN7536529

Produktdetails

Target: FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses FLT4 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human VEGFR-3/FLT-4 Protein

Sequenz: YSMTPPTLNI TEESHVIDTG DSLSISCRGQ HPLEWAWPGA QEAPATGDKD SEDTGVVRDC EGTDARPYCK VLLLHEVHAN DTGSYVCYYK YIKARIEGTT AASSYVFVRD FEQPFINKPD TLLVNRKDAM WVPCLVSIPG LNVTLRSQSS VLWPDGQEVV WDDRRGMLVS TPLLHDALYL QCETTWGDQD FLSNPFLVHI TGNELYDIQL LPRKSLELLV GEKLVLNCTV WAEFNSGVTF DWDYPGKQAE RGKWVPERRS QQTHTELSSI LTIHNVSQHD LGSYVCKANN GIQRFRESTE VIVHENPFIS VEWLKGPILE ATAGDELVKL PVKLAAYPPP EFQWYKDGKA LSGRHSPHAL VLKEVTEAST GTYTLALWNS AAGLRRNISL ELVVNVPPQI HEKEASSPSI YSRHSRQALT CTAYGVPLPL SIQWHWRPWT PCKMFAQRSL RRRQQQDLMP QCRDWRAVTT QDAVNPIESL DTWTEFVEGK NKTVSKLVIQ NANVSAMYKC VVSNKVGQDE RLIYFYVTTI PDGFTIESKP SEELLEGQPV LLSCQADSYK YEHLRWYRLN LSTLHDAHGN PLLLDCKNVH LFATPLAASL EEVAPGARHA TLSLSIPRVA PEHEGHYVCE VQDRRSHDKH CHKKYLSVQA LEAPRLTQNL TDLLVNVSDS LEMQCLVAGA HAPSIVWYKD ERLLEEKSGV DLADSNQKLS IQRVREEDAG RYLCSVCNAK GCVNSSASVA VEGSEDKGSM EI

Spezifität: Tyr25-Ile776

Reinheit: > 92 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: < 0.01EU/μg

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Konzentration: 0.61 mg/mL

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Antigendetails

Target: FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

Andere Bezeichnung: VEGFR-3/FLT-4 (FLT4 Produkte)

Synonyme: FLT41 Protein, LMPH1A Protein, PCL Protein, VEGFR3 Protein, AI323512 Protein, Chy Protein, Flt-4 Protein, VEGFR-3 Protein, Vegfr3 Protein, cb1059 Protein, fms related tyrosine kinase 4 Protein, FMS-like tyrosine kinase 4 Protein, fms-related tyrosine kinase 4 Protein, FLT4 Protein, Flt4 Protein, flt4 Protein

Hintergrund:

Description: Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.

Name: PCL, CHTD7, FLT-4, FLT41, LMPH1A, LMPHM1, VEGFR3, VEGFR-3

Gen-ID: 2324

UniProt: P35916

Pathways: RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling