HTR2C Protein

Produktnummer ABIN7538115

Produktdetails

Target: HTR2C (5-Hydroxytryptamine (serotonin) Receptor 2C (HTR2C))

Protein-Typ: Synthetic Nanodisc

Spezies: Human

Quelle: Mammalian Cells

Verwendungszweck: Human 5HT2C full length protein-synthetic nanodisc

Produktmerkmale: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Anwendungsinformationen

Kommentare:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: HTR2C (5-Hydroxytryptamine (serotonin) Receptor 2C (HTR2C))

Andere Bezeichnung: 5HT2C (HTR2C Produkte)

Synonyme: 5-HT2C Protein, 5-HTR2C Protein, HTR1C Protein, 5-HT2cR Protein, 5HT1c Protein, Htr1c Protein, SR1 Protein, 5HT-1C Protein, 5HT2C Protein, 5-HT-2C Protein, 5-ht2cr Protein, si:dkey-24g18.2 Protein, 5ht2c Protein, 5HTR2C Protein, 5-hydroxytryptamine receptor 2C Protein, 5-hydroxytryptamine (serotonin) receptor 2C Protein, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled S homeolog Protein, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 Protein, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Protein, HTR2C Protein, Htr2c Protein, htr2c.S Protein, htr2cl1 Protein, LOC407134 Protein

Hintergrund: This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]

Molekulargewicht: The human full length 5HT2C protein has a MW of 51.8kDa

UniProt: P28335

Pathways: Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour