HTR7 Protein

Produktnummer ABIN7538116

Produktdetails

Target: HTR7 (5-Hydroxytryptamine (serotonin) Receptor 7 (Adenylate Cyclase-Coupled) (HTR7))

Protein-Typ: Synthetic Nanodisc

Spezies: Human

Quelle: Mammalian Cells

Verwendungszweck: Human 5HT7R full length protein-synthetic nanodisc

Produktmerkmale: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Anwendungsinformationen

Kommentare:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: HTR7 (5-Hydroxytryptamine (serotonin) Receptor 7 (Adenylate Cyclase-Coupled) (HTR7))

Andere Bezeichnung: 5HT7R (HTR7 Produkte)

Synonyme: 5-HT7 Protein, 5-HT-dro Protein, 5-HT-dro1 Protein, 5-HT7Dro Protein, 5-HT[7]Dro Protein, 5-HT[[7Dro]] Protein, 5-HT[[7]] Protein, 5-HT[[7]]Dro Protein, 5-HT[[dro1]] Protein, 5-HTdro1 Protein, 5HT-7 Protein, 5HT-R1 Protein, 5HT-dro Protein, 5HT-dro1 Protein, 5HT[[7Dro]] Protein, 5htdror Protein, CG12073 Protein, DRO1 Protein, Dm5HTdro1 Protein, Dmel\\CG12073 Protein, 5Ht7 Protein, 5HT7 Protein, htr7-A Protein, 5-hydroxytryptamine receptor 7 Protein, 5-hydroxytryptamine (serotonin) receptor 7 Protein, 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled Protein, 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled L homeolog Protein, HTR7 Protein, 5-HT7 Protein, LOC752003 Protein, Htr7 Protein, htr7.L Protein

Hintergrund: The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]

Molekulargewicht: The human full length 5HT7R protein has a MW of 53.6kDa

UniProt: P34969

Pathways: JAK-STAT Signalweg