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Adenosine A2a Receptor Protein (ADORA2A)

ADORA2A Spezies: Human Wirt: Mammalian Cells MSP Nanodisc
Produktnummer ABIN7538121
  • Target Alle Adenosine A2a Receptor (ADORA2A) Proteine anzeigen
    Adenosine A2a Receptor (ADORA2A)
    Protein-Typ
    MSP Nanodisc
    Spezies
    • 9
    • 1
    Human
    Quelle
    • 4
    • 3
    • 2
    • 1
    Mammalian Cells
    Verwendungszweck
    Human ADORA2A full length protein membrane nanoparticles (MNPs)
    Produktmerkmale
    Plasma membrane-coated nanoparticles (MNPs) have been used in various applications, including delivery of therapeutic agents and induction of immune responses et al. Unlike the conventional strategies, MNPs directly leverage intact and natural functions of cell membranes, and show high biocompatibility, specificity, and low side effects. Our optimized MNPs platform for the full-length membrane protein production uses membrane coating technology and a HEK293 based expression platform. The high-purity plasma membrane-coated nanoparticles were produced by extrusion after membrane extraction from the host HEK293 cells containing the overexpressed target proteins.
    Top Product
    Discover our top product ADORA2A Protein
  • Kommentare

    Advantages of Membrane Nanoparticles (MNPs):

    • High display density of target membrane proteins
    • Native structure and orientation of transmembrane protein
    • soluble in aqueous solutions for routine biochemical analysis
    • Detergent-free purification process
    • Strong immunogenicity
    • Works for MPs that can´t be produced via VLPs and EXos
    Limitations of Membrane Nanoparticles (MNPs):
    • Lack of accurate quantification of the target membrane proteins.
    • Need to develop special SPR assayx.
    • Cell membranes contain housekeeping proteins that can result in immune response dilution.
    • Some membrane proteins can´t be enriched on membrane.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Haltbarkeit
    12 months
  • Target
    Adenosine A2a Receptor (ADORA2A)
    Andere Bezeichnung
    ADORA2A (ADORA2A Produkte)
    Synonyme
    ADORA2A Protein, adora2a.1 Protein, zgc:194773 Protein, A2aR Protein, ADORA2 Protein, RDC8 Protein, A2AAR Protein, AA2AR Protein, A2ar Protein, ADENO Protein, Adora2l1 Protein, adora2a.2 Protein, zgc:193802 Protein, zgc:193822 Protein, adenosine A2a receptor Protein, adenosine A2a receptor a Protein, adenosine A2a receptor L homeolog Protein, adenosine A2a receptor b Protein, ADORA2A Protein, Adora2a Protein, adora2aa Protein, adora2a.L Protein, adora2a Protein, adora2ab Protein
    Hintergrund
    A member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.
    Molekulargewicht
    The human full length ADORA2A protein has a MW of 44.7 kDa
    UniProt
    P29274
    Pathways
    Neurotrophin Signalübertragung, cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour, Cancer Immune Checkpoints
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