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Calcitonin Receptor Protein (CALCR)

CALCR Spezies: Human Wirt: Mammalian Cells Synthetic Nanodisc
Produktnummer ABIN7538150
  • Target Alle Calcitonin Receptor (CALCR) Proteine anzeigen
    Calcitonin Receptor (CALCR)
    Protein-Typ
    Synthetic Nanodisc
    Spezies
    • 3
    • 1
    • 1
    Human
    Quelle
    • 3
    • 2
    Mammalian Cells
    Verwendungszweck
    Human CALCR full length protein-synthetic nanodisc
    Produktmerkmale
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
    Top Product
    Discover our top product CALCR Protein
  • Kommentare

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Haltbarkeit
    12 months
  • Target
    Calcitonin Receptor (CALCR)
    Andere Bezeichnung
    CALCR (CALCR Produkte)
    Synonyme
    CALCR Protein, si:ch211-77k19.2 Protein, calcr Protein, CRT Protein, CT-R Protein, CTR Protein, CTR1 Protein, Clr Protein, Ct-R Protein, calcitonin receptor Protein, CALCR Protein, calcr Protein, Calcr Protein
    Hintergrund
    This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
    Molekulargewicht
    The human full length CALCR protein has a MW of 55.3kDa
    UniProt
    P30988
    Pathways
    cAMP Metabolic Process
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