CD276 Protein (CD276) (AA 29-465) (His tag)

Produktnummer ABIN7538169

Produktdetails

Target: CD276

Protein-Typ: Recombinant

Proteineigenschaft: AA 29-465

Spezies: Cynomolgus

Quelle: Mammalian Cells

Aufreinigungstag / Konjugat: Dieses CD276 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Cynomolgus B7-H3 protein with C-terminal 10xHis tag

Spezifität: B7-H3 (Leu29-Glu465) 10xHis tag

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Reinheit: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: CD276

Andere Bezeichnung: B7-H3 (CD276 Produkte)

Synonyme: sc:d0645 Protein, zgc:158279 Protein, 6030411F23Rik Protein, AU016588 Protein, B7RP-2 Protein, B7h3 Protein, B7H3 Protein, 4Ig-B7-H3 Protein, B7-H3 Protein, CD276 molecule Protein, CD276 molecule S homeolog Protein, CD276 antigen Protein, Cd276 molecule Protein, CD276 Protein, cd276.S Protein, cd276 Protein, Cd276 Protein

Hintergrund: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Molekulargewicht: predicted molecular mass of 48.4 kDa after removal of the signal peptide. The apparent molecular mass of cB7-H3-His is 55-100 kDa due to glycosylation.

NCBI Accession: XP_015308534

Pathways: Cancer Immune Checkpoints